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Aging

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Study suggests antibiotic Rapamycin delays aging

Here's an interesting note. An antibiotic seems to delay aging in mice even if treatment starts late in life...

A new star has appeared in the field of drugs that delay aging in laboratory animals, and are therefore candidates for doing the same in people.

The drug is an antibiotic, rapamycin, already in use for suppressing the immune system in transplant patients and for treating certain cancers.

Rapamycin treatment had the remarkable effect of extending life even though it was not started in the right dose until the mice had lived 600 days — equivalent to a person at age 60. Most interventions that prolong life in mice, including a very low-calorie diet, need to be started early in life to show any effect.

Link: http://www.nytimes.com/2009/07/09/health/research/09aging.html

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Red wine and aging: Resveratrol activates anti-aging protein sirtuin

Here's another reason why that glass of red wine may be good for you: scientists have identified a possible mechanism of action. Apparently, an ingredient in red wine, resveratrol, activates sirtuin, a protein that restores chromosomes to proper functioning. According to a recent story in the New York Times:

A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health.

The finding, published online Wednesday in the journal Cell, is from a group led by David Sinclair of the Harvard Medical School. It is part of a growing effort by biologists to understand the sirtuins and other powerful agents that control the settings on the living cell’s metabolism, like its handling of fats and response to insulin.
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