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"Honey", a digital painting by Catrina

Our daughter, Catrina, has completed her first all-digital work.

Honey, a digital painting of a Chihuahua by Catrina

"Honey", by Catrina Curry

You can see more of her works in her gallery.

Update: You can purchase Honey the Apple-headed Chihuahua on a coffee mug and other products on zazzle.com Tell us what you think!

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Our daughter's portrait drawings...

My daughter, Catrina, has been working on more of her fantastic portrait drawings. You can see some of them, including her more recent works, on her gallery.

Oh, and in case you didn't know, we've been using her portrait of Norma Jeane Baker (AKA Marilyn Monroe) for the site logo for a while now... As you can see, Catrina has an affinity for classic movie stars and starlets.

Norma Jeane Baker Portrait by Catrina
Graphite portrait of Hedy Lamarr by Catrina
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Are all calories the same?

I've been skeptical about the claimed metabolic advantage of low-carb diets. It sounds almost too good to be true, like magic: somehow, dieters on a low-carb diet lose more weight when on a low-carb diet compared to other types of diets (with identical caloric intake).

I've been looking for science-based evidence of the advantage before accepting it as real.

Reading Dr. Eades' blog entry (proteinpower.com) today provided some enlightening information on the subject. There are interesting quotes from previous posts, describing the metabolic processes that might lead to the metabolic advantage.

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Are doctors glorified drug peddlers?

Is it ethical for a doctor to talk up a drug in exchange for payments from drug companies?

You may be unaware of a practice that is considered 'ethical' conduct between drug companies and doctors. Doctors are offered compensation to give talks to other doctors about the benefits of certain drugs.

Here's an interesting story from a doctor on the receiving end of drug company 'incentives'. The story begins:

On a blustery fall New England day in 2001, a friendly representative from Wyeth Pharmaceuticals came into my office in Newburyport, Mass., and made me an offer I found hard to refuse. He asked me if I’d like to give talks to other doctors about using Effexor XR for treating depression. He told me that I would go around to doctors’ offices during lunchtime and talk about some of the features of Effexor. It would be pretty easy. Wyeth would provide a set of slides and even pay for me to attend a speaker’s training session, and he quickly floated some numbers. I would be paid $500 for one-hour “Lunch and Learn” talks at local doctors’ offices, or $750 if I had to drive an hour. I would be flown to New York for a “faculty-development program,” where I would be pampered in a Midtown hotel for two nights and would be paid an additional “honorarium.”

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Lipophobes and Statinators, Oh My!

Dr. Michael Eades (www.proteinpower.com) uses the terms Lipophobe and Statinator to describe the seemingly single-mindedness of some in the medical establishment, often sounding like broken records... "Cut the fat!" "Reduce Cholesterol!"

His posts are a usually lengthy but well worth the read. Go on over and check them out!

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Why do we "go off" our plans? Brain chemistry!

Why do we go off-program when we know better?

Why do we allow temptation to derail us?

Jonah Lehrer, author of How We Decide, describes the battles in our brains, in an experiment that may help us understand why we choose things that aren't always best for us.

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Aspirin improves survival rates for colorectal cancer victims -- study

Aspirin, the wonder drug...

Here's yet another news item describing an apparent beneficial side-effect of aspirin use:

Aspirin Seen Aiding Colorectal Cancer Patients

It has long been known that people who took aspirin regularly were less likely to develop tumors of the colon, and now a study has found that even after a diagnosis of colorectal cancer, patients who took aspirin had a much better chance of surviving than non-users.
...
The paper was based on an observational study that followed 1,279 men and women with nonmetastatic colorectal cancer, and thus was not the kind of randomized controlled clinical trial considered the gold standard for determining the course of treatment in medicine.

What lends credence to the results is that doctors understand the biological mechanism by which aspirin may prevent the growth and slow the spread of colon cancer, since most colorectal cancer tumors are positive for cyclooxygenase-2, or COX-2, an enzyme that is not expressed in a healthy colon but flares up under certain circumstances, and aspirin is a COX-2 inhibitor.

Link

So, it's not quite conclusive... but it's still interesting, isn't it?

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Study suggests antibiotic Rapamycin delays aging

Here's an interesting note. An antibiotic seems to delay aging in mice even if treatment starts late in life...

A new star has appeared in the field of drugs that delay aging in laboratory animals, and are therefore candidates for doing the same in people.

The drug is an antibiotic, rapamycin, already in use for suppressing the immune system in transplant patients and for treating certain cancers.

Rapamycin treatment had the remarkable effect of extending life even though it was not started in the right dose until the mice had lived 600 days — equivalent to a person at age 60. Most interventions that prolong life in mice, including a very low-calorie diet, need to be started early in life to show any effect.

Link: http://www.nytimes.com/2009/07/09/health/research/09aging.html

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Health news roundup: More coffee goodness, large waistline a risk factor for Alzheimers

Here's a quick list of interesting health-related news articles I stumbled across, courtesy of the BBC news web site.

Coffee may reverse Alzheimers

Drinking five cups of coffee a day could reverse memory problems seen in Alzheimer's disease, US scientists say.

The Florida research, carried out on mice, also suggested caffeine hampered the production of the protein plaques which are the hallmark of the disease.

Link: http://news.bbc.co.uk/2/hi/health/8132122.stm

Large waist in middle age 'an Alheimer's risk'

A big waistline in your 40s could almost triple the threat of dementia in old age, according to US research.

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Diets high in animal fats may increase risk of pancreatic cancer

This could be a bit of bad news if you do the low carb diet thing and eat unlimited quantities of meat, bacon, hot dogs, etc. It appears that heavy intake of meats and animal fats may increase your risk of pancreatic cancer, according to a recent study:

Researchers followed 500,000 people who had completed a food diary for an average of six years.

The Journal of the National Cancer Institute paper found those who had the most animal fats in their diet had a higher risk of developing the cancer.

UK experts said cutting down on the fats was a way of reducing risk.

There has previously been confusion over whether there was a link between animal fats and pancreatic cancer, with different studies reaching opposite conclusions.

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Sleep loss may lead to weight gains and elevated risk of diabetes, research suggests

Eve Van Cauter, a researcher at the University of Chicago, finds that sleep loss coincides with an increase in the odds of weight gain and increased risk of Type 2 diabetes.

ScienceDaily (Apr. 21, 2009) — Laboratory and epidemiological studies continue to show that sleep curtailment and/or decreased sleep quality can disturb neuroendocrine control of appetite, leading to overeating, and can decrease insulin and/or increase insulin resistance, both steps on the road to Type 2 diabetes.

[snip]

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Diet Food Packaging, Marketing, and the Halo Effect

People are irrational.

I've observed over the years that many people assume that the term LOW FAT means NON-FATTENING or HEALTHY. That they can eat as much of that stuff as they want, and it will only make them healthier. I blame the simplistic "fat bad, carbs good" education campaign for much of this bizarre behavior.

The overwhelming evidence shows that the best way to improved health and longevity is through overall caloric reduction (note that I'm not advocating a simplistic low-fat or low-carb lifestyle, only that reducing overall caloric intake seems to be the key component of improving fitness.)

I can't tell you how many times I've heard someone say "It's fat free! and proceed to eat an economy-sized helping. Reading the ingredients label usually shows sugar or high fructose corn syrup as the second or third ingredient.

I'm not the only one who has concluded that people are just plain nuts when it comes to food packaging and labeling. Check out the following stories:

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Red wine and aging: Resveratrol activates anti-aging protein sirtuin

Here's another reason why that glass of red wine may be good for you: scientists have identified a possible mechanism of action. Apparently, an ingredient in red wine, resveratrol, activates sirtuin, a protein that restores chromosomes to proper functioning. According to a recent story in the New York Times:

A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health.

The finding, published online Wednesday in the journal Cell, is from a group led by David Sinclair of the Harvard Medical School. It is part of a growing effort by biologists to understand the sirtuins and other powerful agents that control the settings on the living cell’s metabolism, like its handling of fats and response to insulin.
Link

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Warning: Daylight Savings Time May Be Harmful to Your Health

I've always had this nagging suspicion that daylight savings time might be responsible for a variety of deleterious health effects -- including things like increases in traffic accidents and other operator-related incidents -- so it came as no surprise when I read the following news blurb:

When researchers in Sweden examined the impact of daylight saving time on heart attack rates in that country, they discovered that people had slightly fewer heart attacks on the Monday after they set their clocks back in the fall and slightly more heart attacks in the days after they set their clocks ahead in the spring.

They presented their findings in a letter published in the Oct. 30 issue of The New England Journal of Medicine.

[snip]

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Half of Doctors Routinely Prescribe Placebos - New York Times

Here's an interesting article in the New York Times, describing widespread use of placebos in treating patients, as a way to treat the patient's mental state rather than the actual problem.

The problem is that the placebos used are not inert -- rather, they prescribe drugs intended for other uses, such as headache pills, sedatives, or other relatively harmless drugs.

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Obese women have exercise 'phobia' - Telegraph

Researchers have discovered -- surprise! -- that obese women are self conscious (and/or fear injury) and those emotions prevent successful exercise:

Obese women may have a 'phobia' of exercise which stops them being active because they feel self-conscious and are afraid of injury, researchers argue.

Far from being excuses to be lazy, these 'mental barriers' are real problems which must be overcome to encourage overweight women to exercise more, a conference was told.

[snip]

[Participants] were asked what factors stopped them from exercising at the start of the programme, three months into it and at the end.

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Pill-popping your way to fitness?

Wired has an interesting story about "exercise in a pill". The article outlines ongoing research into drugs that can mimic the effects of exercise, including, in one study, improving stamina 44 percent in "couch potato" lab mice.

Today, researchers are reporting that an experimental drug can mimic the results of an exercise regimen -- with no exercise required. After four weeks of taking the pill, mice who hadn't worked out displayed a 44 percent increase in their running endurance.

"It’s tricking the muscle into ‘believing’ it’s been exercised daily," said the study's lead researcher, Ronald Evans of the Salk Institute, in a release. "It’s basically the couch potato experiment, and it proves you can have a pharmacologic equivalent to exercise."

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News flash - Another study confirms: low fat diets not as effective as low carb diets

Low fat diets are not the best way to lose weight according to a new study.

The research which looked at more than 300 obese people found those who stuck to a Mediterranean or low carbohydrate diet lost more weight over two years.

Low fat diets are the most commonly recommended diets in the UK to help people lose weight, and also to reduce the risks of heart disease and cancer.

However, researchers led by a team at Ben-Gurion University of the Negev, in Israel, found those on a Mediterranean diet lost on average 60 per cent more weight.

Link (telegraph.co.uk)

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The Incredible Shrinking Woman

I'm watching my wife (LowCarbForLife) shrink before my eyes. Her body is being transformed by her dedication to the CAD/CALP lifestyle and her surprising (to me, anyway) enthusiasm for regular aerobic and weight training exercises.

I know she can't really see it, and we didn't take a 'before' picture (she's too modest for that), so we don't have an objective, visual way to compare her current shape to what it was when she started only a few months ago. But I can see the changes every week, and I can feel them as well -- when I put my arms around her, she feels like a different person, except that I remember that this is how it felt a long time ago... (yes, I remember.)

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